FBXO38 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXO38 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO38
  * **<color #00a2e8>Official Name</color>**: F-box protein 38
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81545|81545]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PIJ6|Q6PIJ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO38&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO38|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of T cell mediated immune response to tumor cell|
|regulation of T cell mediated immune response to tumor cell|
|positive regulation of immune response to tumor cell|
|positive regulation of response to tumor cell|
|regulation of immune response to tumor cell|
|regulation of response to tumor cell|
|positive regulation of T cell mediated immunity|
|protein K48-linked ubiquitination|
|SCF ubiquitin ligase complex|
|regulation of T cell mediated immunity|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of leukocyte mediated immunity|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|positive regulation of neuron projection development|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|positive regulation of response to biotic stimulus|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|adaptive immune response|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|proteolysis|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.53|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.27|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.14|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.97|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.94|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.87|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16887
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO38 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>