FBXO38

Gene Information

Official Symbol: FBXO38
Official Name: F-box protein 38
Aliases and Previous Symbols: N/A
Entrez ID: 81545
UniProt: Q6PIJ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
UniProt Summary: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Radicicol 0.16μM R05 exp242	-2.53
TGF-beta1 44ng/ml R08 exp528	-2.27
BML-284 0.09μM R08 exp460	-2.14
Etoposide 10μM R00 exp20	-1.97
IU1-47 25μM R04 exp182	-1.94
GSK626616 14μM R08 exp485	-1.87
Tubastatin-A 2.5μM R07 exp417	1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16887
Expression level (log2 read counts): 4.87

Expression Distribution

positive regulation of T cell mediated immune response to tumor cell
regulation of T cell mediated immune response to tumor cell
positive regulation of immune response to tumor cell
positive regulation of response to tumor cell
regulation of immune response to tumor cell
regulation of response to tumor cell
positive regulation of T cell mediated immunity
protein K48-linked ubiquitination
SCF ubiquitin ligase complex
regulation of T cell mediated immunity
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of adaptive immune response
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte mediated immunity
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
regulation of adaptive immune response
regulation of leukocyte mediated immunity
positive regulation of immune effector process
positive regulation of neuron projection development
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
positive regulation of response to biotic stimulus
positive regulation of neuron differentiation
positive regulation of cell projection organization
regulation of immune effector process
positive regulation of neurogenesis
regulation of neuron projection development
regulation of response to biotic stimulus
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
positive regulation of nervous system development
positive regulation of cell development
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
adaptive immune response
cellular protein catabolic process
regulation of neuron differentiation