FBXO4

Gene Information

Official Symbol: FBXO4
Official Name: F-box protein 4
Aliases and Previous Symbols: N/A
Entrez ID: 26272
UniProt: Q9UKT5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. {ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11720
Expression level (log2 read counts): 3.4

Expression Distribution

F-box-like
F-box

common myeloid progenitor cell proliferation
positive regulation of protein polyubiquitination
regulation of DNA damage checkpoint
regulation of protein polyubiquitination
negative regulation of fibroblast proliferation
negative regulation of protein localization to nucleus
regulation of cell cycle checkpoint
positive regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomere lengthening
protein destabilization
positive regulation of telomere maintenance
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
SCF ubiquitin ligase complex
positive regulation of DNA biosynthetic process
cellular response to ionizing radiation
regulation of fibroblast proliferation
regulation of telomere maintenance
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
ubiquitin ligase complex
negative regulation of cellular protein localization
regulation of DNA biosynthetic process
positive regulation of protein ubiquitination
regulation of protein localization to nucleus
positive regulation of protein modification by small protein conjugation or removal
response to ionizing radiation
positive regulation of chromosome organization
cellular response to radiation
positive regulation of DNA metabolic process
regulation of protein ubiquitination
regulation of response to DNA damage stimulus
ubiquitin protein ligase activity
regulation of protein modification by small protein conjugation or removal
ubiquitin-protein transferase activity
aging
regulation of protein stability
protein polyubiquitination
cellular response to environmental stimulus
cellular response to abiotic stimulus
proteasome-mediated ubiquitin-dependent protein catabolic process