FBXW8

Gene Information

Official Symbol: FBXW8
Official Name: F-box and WD repeat domain containing 8
Aliases and Previous Symbols: N/A
Entrez ID: 26259
UniProt: Q8N3Y1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13475
Expression level (log2 read counts): 4.65

Expression Distribution

F-box-like
F-box

3M complex
Cul7-RING ubiquitin ligase complex
positive regulation of dendrite morphogenesis
positive regulation of dendrite development
regulation of dendrite morphogenesis
Golgi organization
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
ubiquitin-protein transferase activity
positive regulation of neuron projection development
protein polyubiquitination
regulation of cell morphogenesis involved in differentiation
post-translational protein modification
positive regulation of neuron differentiation
positive regulation of cell projection organization
endomembrane system organization
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
cell population proliferation
regulation of neuron differentiation
protein ubiquitination
regulation of plasma membrane bounded cell projection organization
perinuclear region of cytoplasm
regulation of cell projection organization
protein modification by small protein conjugation
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
Golgi apparatus
protein modification by small protein conjugation or removal
regulation of anatomical structure morphogenesis
positive regulation of cellular component organization
positive regulation of developmental process
generation of neurons
neurogenesis
positive regulation of multicellular organismal process