FCER2

Gene Information

Official Symbol: FCER2
Official Name: Fc fragment of IgE receptor II
Aliases and Previous Symbols: N/A
Entrez ID: 2208
UniProt: P06734
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
UniProt Summary: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12768
Expression level (log2 read counts): 1.83

Expression Distribution

positive regulation of humoral immune response mediated by circulating immunoglobulin
IgE binding
regulation of humoral immune response mediated by circulating immunoglobulin
positive regulation of killing of cells of other organism
positive regulation of nitric-oxide synthase biosynthetic process
regulation of killing of cells of other organism
positive regulation of humoral immune response
regulation of nitric-oxide synthase biosynthetic process
positive regulation of nitric-oxide synthase activity
positive regulation of monooxygenase activity
positive regulation of immunoglobulin mediated immune response
positive regulation of B cell mediated immunity
regulation of nitric-oxide synthase activity
regulation of B cell mediated immunity
regulation of immunoglobulin mediated immune response
positive regulation of oxidoreductase activity
regulation of monooxygenase activity
positive regulation of cell killing
regulation of oxidoreductase activity
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of adaptive immune response
Notch signaling pathway
integrin binding
positive regulation of leukocyte mediated immunity
regulation of humoral immune response
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
regulation of adaptive immune response
carbohydrate binding
regulation of leukocyte mediated immunity
positive regulation of immune effector process
external side of plasma membrane
regulation of immune effector process
positive regulation of multi-organism process
cytokine-mediated signaling pathway
regulation of multi-organism process
positive regulation of immune response
cellular response to cytokine stimulus