FCGR2B [The Human Chemical-Genetic Interaction Map Project]

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======= FCGR2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FCGR2B
  * **<color #00a2e8>Official Name</color>**: Fc fragment of IgG receptor IIb
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2213|2213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31994|P31994]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FCGR2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FCGR2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of type IIa hypersensitivity|
|regulation of B cell antigen processing and presentation|
|immune complex clearance by monocytes and macrophages|
|negative regulation of antibody-dependent cellular cytotoxicity|
|negative regulation of type I hypersensitivity|
|low-affinity IgG receptor activity|
|negative regulation of type II hypersensitivity|
|immune complex clearance|
|negative regulation of hypersensitivity|
|negative regulation of cytotoxic T cell degranulation|
|regulation of immune complex clearance by monocytes and macrophages|
|regulation of cytotoxic T cell degranulation|
|follicular B cell differentiation|
|regulation of antibody-dependent cellular cytotoxicity|
|follicular dendritic cell activation|
|regulation of type I hypersensitivity|
|negative regulation of dendritic cell antigen processing and presentation|
|regulation of type II hypersensitivity|
|regulation of type IIa hypersensitivity|
|negative regulation of acute inflammatory response to antigenic stimulus|
|negative regulation of neutrophil activation|
|negative regulation of dendritic cell differentiation|
|negative regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of T cell mediated cytotoxicity|
|negative regulation of B cell receptor signaling pathway|
|regulation of hypersensitivity|
|negative regulation of antigen processing and presentation|
|negative regulation of B cell mediated immunity|
|negative regulation of immunoglobulin mediated immune response|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of immunoglobulin production|
|regulation of dendritic cell antigen processing and presentation|
|IgG binding|
|regulation of dendritic spine maintenance|
|negative regulation of myeloid leukocyte mediated immunity|
|regulation of neutrophil activation|
|negative regulation of inflammatory response to antigenic stimulus|
|negative regulation of humoral immune response|
|negative regulation of acute inflammatory response|
|regulation of acute inflammatory response to antigenic stimulus|
|negative regulation of leukocyte degranulation|
|regulation of dendritic cell differentiation|
|negative regulation of macrophage activation|
|negative regulation of B cell proliferation|
|positive regulation of humoral immune response|
|negative regulation of leukocyte mediated cytotoxicity|
|mature B cell differentiation involved in immune response|
|negative regulation of interleukin-10 production|
|negative regulation of T cell mediated immunity|
|negative regulation of phagocytosis|
|regulation of antigen processing and presentation|
|negative regulation of cell killing|
|mast cell activation|
|mature B cell differentiation|
|regulation of inflammatory response to antigenic stimulus|
|negative regulation of regulated secretory pathway|
|regulation of B cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|negative regulation of B cell activation|
|regulation of T cell mediated cytotoxicity|
|negative regulation of exocytosis|
|negative regulation of production of molecular mediator of immune response|
|positive regulation of response to endoplasmic reticulum stress|
|negative regulation of lymphocyte mediated immunity|
|cellular response to amyloid-beta|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|B cell activation involved in immune response|
|regulation of acute inflammatory response|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte mediated immunity|
|response to amyloid-beta|
|regulation of leukocyte degranulation|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of interleukin-10 production|
|regulation of macrophage activation|
|regulation of myeloid leukocyte mediated immunity|
|regulation of B cell proliferation|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of immunoglobulin production|
|negative regulation of cytokine secretion|
|positive regulation of phagocytosis|
|regulation of T cell mediated immunity|
|cell body|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|regulation of leukocyte mediated cytotoxicity|
|negative regulation of leukocyte proliferation|
|amyloid-beta binding|
|regulation of response to endoplasmic reticulum stress|
|positive regulation of neuron death|
|regulation of phagocytosis|
|regulation of postsynapse organization|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|negative regulation of leukocyte differentiation|
|regulation of cell killing|
|cerebellum development|
|B cell differentiation|
|negative regulation of T cell activation|
|lymphocyte activation involved in immune response|
|metencephalon development|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|phagocytosis, engulfment|
|negative regulation of protein secretion|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|negative regulation of inflammatory response|
|negative regulation of hemopoiesis|
|regulation of humoral immune response|
|Fc receptor mediated stimulatory signaling pathway|
|plasma membrane invagination|
|positive regulation of JNK cascade|
|negative regulation of peptide secretion|
|Fc-gamma receptor signaling pathway|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|membrane invagination|
|dendritic spine|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|hindbrain development|
|B cell activation|
|regulation of adaptive immune response|
|regulation of regulated secretory pathway|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of signaling receptor activity|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|antigen processing and presentation of exogenous peptide antigen|
|negative regulation of protein transport|
|antigen processing and presentation of exogenous antigen|
|regulation of JNK cascade|
|negative regulation of establishment of protein localization|
|antigen processing and presentation of peptide antigen|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|negative regulation of defense response|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|B cell mediated immunity|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|antigen processing and presentation|
|regulation of synapse organization|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|regulation of synapse structure or activity|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|lymphocyte differentiation|
|receptor-mediated endocytosis|
|Fc receptor signaling pathway|
|lymphocyte mediated immunity|
|protein-containing complex binding|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of leukocyte cell-cell adhesion|
|regulation of neuron death|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|cellular response to peptide|
|phagocytosis|
|leukocyte differentiation|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of protein secretion|
|regulation of immune effector process|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|endocytosis|
|hemopoiesis|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|import into cell|
|regulation of cell adhesion|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|positive regulation of cell death|
|viral process|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|membrane organization|
|positive regulation of immune response|
|leukocyte activation|
|negative regulation of developmental process|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FCGR2B Expression in NALM6 Cells: 1.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>