FCHO1

Entrez Summary: N/A
UniProt Summary: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. {ECO:0000269|PubMed:20448150}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

FCH
muHD

AP-2 adaptor complex binding
AP-2 adaptor complex
plasma membrane tubulation
clathrin coat assembly
clathrin-dependent endocytosis
clathrin-coated pit
tubulin binding
clathrin-coated vesicle
cytoskeletal protein binding
plasma membrane organization
phospholipid binding
receptor-mediated endocytosis
microtubule binding
cytoskeleton
endomembrane system organization
endocytosis
import into cell
cellular protein-containing complex assembly
membrane organization
protein-containing complex assembly
protein-containing complex subunit organization
vesicle-mediated transport