FCHO2 [The Human Chemical-Genetic Interaction Map Project]

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======= FCHO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FCHO2
  * **<color #00a2e8>Official Name</color>**: FCH and mu domain containing endocytic adaptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=115548|115548]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q0JRZ9|Q0JRZ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FCHO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FCHO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613438|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FCH|
|muHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|presynaptic endocytic zone membrane|
|AP-2 adaptor complex|
|plasma membrane tubulation|
|clathrin coat assembly|
|clathrin-dependent endocytosis|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|synaptic vesicle recycling|
|tubulin binding|
|clathrin-coated pit|
|clathrin-coated vesicle|
|phosphatidylserine binding|
|cytoskeletal protein binding|
|phosphatidylinositol-4,5-bisphosphate binding|
|phosphatidylinositol binding|
|plasma membrane organization|
|phospholipid binding|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|membrane invagination|
|protein localization to plasma membrane|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|microtubule binding|
|cytoskeleton|
|endomembrane system organization|
|protein localization to membrane|
|endocytosis|
|import into cell|
|cellular protein-containing complex assembly|
|membrane organization|
|identical protein binding|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.85|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.72|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.82|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14156
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FCHO2 Expression in NALM6 Cells: 2.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>