FCHO2

Entrez Summary: N/A
UniProt Summary: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

FCH
muHD

presynaptic endocytic zone membrane
AP-2 adaptor complex
plasma membrane tubulation
clathrin coat assembly
clathrin-dependent endocytosis
presynaptic endocytosis
synaptic vesicle endocytosis
synaptic vesicle recycling
tubulin binding
clathrin-coated pit
clathrin-coated vesicle
phosphatidylserine binding
cytoskeletal protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol binding
plasma membrane organization
phospholipid binding
synaptic vesicle cycle
vesicle-mediated transport in synapse
membrane invagination
protein localization to plasma membrane
protein localization to cell periphery
receptor-mediated endocytosis
microtubule binding
cytoskeleton
endomembrane system organization
protein localization to membrane
endocytosis
import into cell
cellular protein-containing complex assembly
membrane organization
identical protein binding
protein-containing complex assembly
cellular protein localization
cellular macromolecule localization
establishment of localization in cell
protein-containing complex subunit organization
vesicle-mediated transport