FCN1 [The Human Chemical-Genetic Interaction Map Project]

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======= FCN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FCN1
  * **<color #00a2e8>Official Name</color>**: ficolin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2219|2219]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00602|O00602]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FCN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FCN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601252|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins.  However, all these proteins recognize different targets, and are functionally distinct.  Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fibrinogen C|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell surface pattern recognition receptor signaling pathway|
|recognition of apoptotic cell|
|extrinsic component of external side of plasma membrane|
|signaling pattern recognition receptor activity|
|complement activation, lectin pathway|
|sialic acid binding|
|positive regulation of interleukin-8 secretion|
|negative regulation of viral entry into host cell|
|regulation of interleukin-8 secretion|
|protein localization to cell surface|
|regulation of viral entry into host cell|
|apoptotic cell clearance|
|positive regulation of interleukin-8 production|
|collagen trimer|
|G protein-coupled receptor binding|
|regulation of interleukin-8 production|
|negative regulation of viral life cycle|
|negative regulation of viral process|
|phagocytosis, recognition|
|secretory granule lumen|
|innate immune response activating cell surface receptor signaling pathway|
|ficolin-1-rich granule lumen|
|pattern recognition receptor signaling pathway|
|positive regulation of cytokine secretion|
|regulation of viral life cycle|
|carbohydrate binding|
|complement activation|
|regulation of cytokine secretion|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|innate immune response-activating signal transduction|
|cell recognition|
|activation of innate immune response|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|phagocytosis|
|positive regulation of innate immune response|
|humoral immune response|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|endocytosis|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|import into cell|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FCN1 Expression in NALM6 Cells: 1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>