FCN1

Entrez Summary: The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008].
UniProt Summary: Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Fibrinogen C
Collagen

cell surface pattern recognition receptor signaling pathway
recognition of apoptotic cell
extrinsic component of external side of plasma membrane
signaling pattern recognition receptor activity
complement activation, lectin pathway
sialic acid binding
positive regulation of interleukin-8 secretion
negative regulation of viral entry into host cell
regulation of interleukin-8 secretion
protein localization to cell surface
regulation of viral entry into host cell
apoptotic cell clearance
positive regulation of interleukin-8 production
collagen trimer
G protein-coupled receptor binding
regulation of interleukin-8 production
negative regulation of viral life cycle
negative regulation of viral process
phagocytosis, recognition
secretory granule lumen
innate immune response activating cell surface receptor signaling pathway
ficolin-1-rich granule lumen
pattern recognition receptor signaling pathway
positive regulation of cytokine secretion
regulation of viral life cycle
carbohydrate binding
complement activation
regulation of cytokine secretion
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
innate immune response-activating signal transduction
cell recognition
activation of innate immune response
positive regulation of protein secretion
positive regulation of peptide secretion
phagocytosis
positive regulation of innate immune response
humoral immune response
positive regulation of response to biotic stimulus