FDX1 [The Human Chemical-Genetic Interaction Map Project]

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======= FDX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FDX1
  * **<color #00a2e8>Official Name</color>**: ferredoxin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2230|2230]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10109|P10109]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FDX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FDX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fer2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to forskolin|
|response to forskolin|
|response to platelet aggregation inhibitor|
|C21-steroid hormone biosynthetic process|
|2 iron, 2 sulfur cluster binding|
|C21-steroid hormone metabolic process|
|steroid hormone biosynthetic process|
|cellular response to cAMP|
|hormone biosynthetic process|
|electron transfer activity|
|cellular response to alcohol|
|cellular response to ketone|
|response to cAMP|
|cellular response to antibiotic|
|cholesterol metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|iron ion binding|
|sterol metabolic process|
|response to organophosphorus|
|response to purine-containing compound|
|electron transport chain|
|response to ketone|
|hormone metabolic process|
|response to alcohol|
|steroid metabolic process|
|response to antibiotic|
|alcohol metabolic process|
|mitochondrial matrix|
|cellular response to drug|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|cellular response to lipid|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|lipid biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|response to lipid|
|response to organic cyclic compound|
|oxidation-reduction process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.92|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.78|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.84|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.99|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.22|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dld|DLD]]|0.628|
|[[:human genes:s:slc25a19|SLC25A19]]|0.554|
|[[:human genes:l:lipt1|LIPT1]]|0.551|
|[[:human genes:l:lias|LIAS]]|0.525|
|[[:human genes:i:isca2|ISCA2]]|0.439|
|[[:human genes:n:nfu1|NFU1]]|0.434|
|[[:human genes:l:lipt2|LIPT2]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1202
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FDX1 Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>