FDX1

Entrez Summary: N/A
UniProt Summary: Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to forskolin
response to forskolin
response to platelet aggregation inhibitor
C21-steroid hormone biosynthetic process
2 iron, 2 sulfur cluster binding
C21-steroid hormone metabolic process
steroid hormone biosynthetic process
cellular response to cAMP
hormone biosynthetic process
electron transfer activity
cellular response to alcohol
cellular response to ketone
response to cAMP
cellular response to antibiotic
cholesterol metabolic process
cellular hormone metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
sterol metabolic process
response to organophosphorus
response to purine-containing compound
electron transport chain
response to ketone
hormone metabolic process
response to alcohol
steroid metabolic process
response to antibiotic
alcohol metabolic process
mitochondrial matrix
cellular response to drug
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
cellular response to lipid
regulation of hormone levels
cellular response to organic cyclic compound
lipid biosynthetic process
cellular response to organonitrogen compound
cellular response to nitrogen compound
response to lipid