LIAS

Entrez Summary: The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 5μM R03 exp102	-3
QNZ 0.01μM R05 exp241	-2.6
HMS-I1 1μM R01 exp46	-2.1
CCCP 0.1μM R00 exp10	-1.89
QNZ 0.01μM R08 exp439	-1.87
Rotenone 0.07μM R08 exp431	-1.86
Ammonium tetrathiomolybdate 10μM R08 exp448	1.81
Cannabidiol 13μM R08 exp465	1.92
Calcium Ionophore 0.4μM R07 exp342	2.21
AICAR 240μM R03 exp116	2.25
AICAR 240μM R05 exp211	3.38

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	4/33
central nervous system	0/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lipoate biosynthetic process
lipoate synthase activity
lipoate metabolic process
4 iron, 4 sulfur cluster binding
neural tube closure
tube closure
primary neural tube formation
neural tube formation
fatty acid biosynthetic process
embryonic epithelial tube formation
epithelial tube formation
coenzyme biosynthetic process
morphogenesis of embryonic epithelium
tube formation
neural tube development
sulfur compound biosynthetic process
monocarboxylic acid biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
epithelial tube morphogenesis
response to lipopolysaccharide
fatty acid metabolic process
response to molecule of bacterial origin
sulfur compound metabolic process
mitochondrial matrix
response to oxidative stress
morphogenesis of an epithelium
cofactor metabolic process
inflammatory response
monocarboxylic acid metabolic process
tissue morphogenesis
embryonic morphogenesis
lipid biosynthetic process
small molecule biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
tube morphogenesis
response to bacterium