FES [The Human Chemical-Genetic Interaction Map Project]

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======= FES =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FES
  * **<color #00a2e8>Official Name</color>**: FES proto-oncogene, tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2242|2242]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07332|P07332]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FES&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FES|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|SH2|
|FCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of monocyte differentiation|
|cellular response to vitamin D|
|regulation of monocyte differentiation|
|positive regulation of actin cytoskeleton reorganization|
|cellular response to vitamin|
|positive regulation of microtubule polymerization|
|response to vitamin D|
|regulation of mast cell degranulation|
|positive regulation of microtubule polymerization or depolymerization|
|regulation of mast cell activation involved in immune response|
|regulation of actin cytoskeleton reorganization|
|regulation of mast cell activation|
|non-membrane spanning protein tyrosine kinase activity|
|regulation of leukocyte degranulation|
|regulation of microtubule polymerization|
|positive regulation of myeloid leukocyte differentiation|
|regulation of myeloid leukocyte mediated immunity|
|extrinsic component of cytoplasmic side of plasma membrane|
|cellular response to nutrient|
|regulation of microtubule polymerization or depolymerization|
|centrosome cycle|
|phosphatidylinositol binding|
|response to vitamin|
|protein tyrosine kinase activity|
|microtubule bundle formation|
|positive regulation of myeloid cell differentiation|
|microtubule organizing center organization|
|immunoglobulin receptor binding|
|regulation of myeloid leukocyte differentiation|
|positive regulation of protein polymerization|
|peptidyl-tyrosine phosphorylation|
|positive regulation of leukocyte differentiation|
|peptidyl-tyrosine modification|
|microtubule cytoskeleton|
|regulation of cell shape|
|regulation of regulated secretory pathway|
|positive regulation of hemopoiesis|
|regulation of microtubule cytoskeleton organization|
|protein autophosphorylation|
|positive regulation of supramolecular fiber organization|
|regulation of leukocyte mediated immunity|
|response to nutrient|
|positive regulation of immune effector process|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of exocytosis|
|regulation of protein polymerization|
|regulation of myeloid cell differentiation|
|cellular response to nutrient levels|
|microtubule binding|
|positive regulation of protein complex assembly|
|cytoplasmic vesicle|
|cellular response to extracellular stimulus|
|regulation of leukocyte differentiation|
|positive regulation of neuron projection development|
|cellular response to external stimulus|
|regulation of actin cytoskeleton organization|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|focal adhesion|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|regulation of neuron differentiation|
|microtubule-based process|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|response to lipid|
|peptidyl-amino acid modification|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|cell cycle process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|positive regulation of developmental process|
|ATP binding|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.91|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.91|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3237
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FES Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>