FES

Gene Information

Official Symbol: FES
Official Name: FES proto-oncogene, tyrosine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 2242
UniProt: P07332
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3237
Expression level (log2 read counts): -2.01

Expression Distribution

Screen	Score
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.91
MKC9989 10μM R03 exp133	-1.91
VER-155008 3.9μM R06 exp301	1.79

Pkinase
Pkinase Tyr
SH2
FCH

positive regulation of monocyte differentiation
cellular response to vitamin D
regulation of monocyte differentiation
positive regulation of actin cytoskeleton reorganization
cellular response to vitamin
positive regulation of microtubule polymerization
response to vitamin D
regulation of mast cell degranulation
positive regulation of microtubule polymerization or depolymerization
regulation of mast cell activation involved in immune response
regulation of actin cytoskeleton reorganization
regulation of mast cell activation
non-membrane spanning protein tyrosine kinase activity
regulation of leukocyte degranulation
regulation of microtubule polymerization
positive regulation of myeloid leukocyte differentiation
regulation of myeloid leukocyte mediated immunity
extrinsic component of cytoplasmic side of plasma membrane
cellular response to nutrient
regulation of microtubule polymerization or depolymerization
centrosome cycle
phosphatidylinositol binding
response to vitamin
protein tyrosine kinase activity
microtubule bundle formation
positive regulation of myeloid cell differentiation
microtubule organizing center organization
immunoglobulin receptor binding
regulation of myeloid leukocyte differentiation
positive regulation of protein polymerization
peptidyl-tyrosine phosphorylation
positive regulation of leukocyte differentiation
peptidyl-tyrosine modification
microtubule cytoskeleton
regulation of cell shape
regulation of regulated secretory pathway
positive regulation of hemopoiesis
regulation of microtubule cytoskeleton organization
protein autophosphorylation
positive regulation of supramolecular fiber organization