FEV

Entrez Summary: This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008].
UniProt Summary: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269|PubMed:12761502}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ1 0.06μM R08 exp531	1.72
Cyclosporin-A 3μM R07 exp348	1.88

Gene	Correlation
PMM2	0.446
MRPS5	0.404

neuron fate specification
neuron maturation
neuron fate commitment
cell fate specification
anatomical structure maturation
cell maturation
developmental maturation
transcription corepressor activity
cell fate commitment
nuclear speck
sequence-specific DNA binding
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
neuron development
neuron differentiation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
cellular nitrogen compound biosynthetic process
cell development
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of gene expression
gene expression