FEZ1 [The Human Chemical-Genetic Interaction Map Project]

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======= FEZ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FEZ1
  * **<color #00a2e8>Official Name</color>**: fasciculation and elongation protein zeta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9638|9638]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99689|Q99689]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FEZ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FEZ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604825|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FEZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of anterograde axonal transport of mitochondrion|
|positive regulation of anterograde axonal transport of mitochondrion|
|regulation of organelle transport along microtubule|
|negative regulation of autophagosome assembly|
|mitochondrion morphogenesis|
|establishment of mitochondrion localization|
|gamma-tubulin binding|
|regulation of microtubule-based movement|
|negative regulation of macroautophagy|
|regulation of autophagosome assembly|
|negative regulation of organelle assembly|
|regulation of vacuole organization|
|mitochondrion localization|
|protein kinase C binding|
|hippocampus development|
|negative regulation of autophagy|
|protein N-terminus binding|
|limbic system development|
|establishment of cell polarity|
|growth cone|
|regulation of macroautophagy|
|pallium development|
|establishment or maintenance of cell polarity|
|positive regulation of intracellular transport|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|negative regulation of cellular catabolic process|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|positive regulation of neuron projection development|
|axon|
|negative regulation of catabolic process|
|microtubule|
|regulation of autophagy|
|regulation of intracellular transport|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|neuronal cell body|
|axonogenesis|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|forebrain development|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|mitochondrion organization|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|centrosome|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|organelle localization|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17225
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FEZ1 Expression in NALM6 Cells: 1.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>