FEZ1

Entrez Summary: N/A
UniProt Summary: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of anterograde axonal transport of mitochondrion
positive regulation of anterograde axonal transport of mitochondrion
regulation of organelle transport along microtubule
negative regulation of autophagosome assembly
mitochondrion morphogenesis
establishment of mitochondrion localization
gamma-tubulin binding
regulation of microtubule-based movement
negative regulation of macroautophagy
regulation of autophagosome assembly
negative regulation of organelle assembly
regulation of vacuole organization
mitochondrion localization
protein kinase C binding
hippocampus development
negative regulation of autophagy
protein N-terminus binding
limbic system development
establishment of cell polarity
growth cone
regulation of macroautophagy
pallium development
establishment or maintenance of cell polarity
positive regulation of intracellular transport
regulation of organelle assembly
regulation of microtubule-based process
negative regulation of cellular catabolic process
telencephalon development
axon guidance
neuron projection guidance
positive regulation of neuron projection development
axon
negative regulation of catabolic process
microtubule
regulation of autophagy
regulation of intracellular transport
establishment of organelle localization
positive regulation of neuron differentiation
neuronal cell body
axonogenesis