FFAR4

Entrez Summary: This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
UniProt Summary: Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation. {ECO:0000269|PubMed:15619630}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

taste receptor activity
fatty acid binding
detection of chemical stimulus involved in sensory perception of taste
endocytic vesicle
sensory perception of taste
negative regulation of cytokine secretion
hormone secretion
regulation of glucose transmembrane transport
hormone transport
positive regulation of cold-induced thermogenesis
fat cell differentiation
negative regulation of protein secretion
negative regulation of inflammatory response
negative regulation of peptide secretion
regulation of cold-induced thermogenesis
signal release
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of defense response
positive regulation of ERK1 and ERK2 cascade
negative regulation of secretion
negative regulation of cytokine production
regulation of ERK1 and ERK2 cascade
regulation of inflammatory response
negative regulation of response to external stimulus
regulation of protein secretion
negative regulation of transport
detection of chemical stimulus involved in sensory perception
regulation of peptide secretion
detection of chemical stimulus
regulation of hormone levels
sensory perception of chemical stimulus
positive regulation of MAPK cascade
detection of stimulus involved in sensory perception
regulation of transmembrane transport
detection of stimulus
regulation of cytokine production
regulation of protein transport