FGD5

Gene Information
  • Official Symbol: FGD5
  • Official Name: FYVE, RhoGEF and PH domain containing 5
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 152273
  • UniProt: Q6ZNL6
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 5119
  • Expression level (log2 read counts): 2.06

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1