FGF12 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF12
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2257|2257]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61328|P61328]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601513|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. {ECO:0000269|PubMed:27164707}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of voltage-gated sodium channel activity|
|regulation of neuronal action potential|
|regulation of transmission of nerve impulse|
|sodium channel regulator activity|
|positive regulation of sodium ion transport|
|cardiac muscle cell action potential involved in contraction|
|cardiac muscle cell contraction|
|negative regulation of cation channel activity|
|regulation of membrane depolarization|
|cardiac muscle cell action potential|
|regulation of action potential|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|adult locomotory behavior|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|fibroblast growth factor receptor signaling pathway|
|negative regulation of cation transmembrane transport|
|heart contraction|
|regulation of sodium ion transport|
|actin-mediated cell contraction|
|action potential|
|negative regulation of ion transmembrane transport|
|heart process|
|neuromuscular process|
|striated muscle contraction|
|cellular response to fibroblast growth factor stimulus|
|actin filament-based movement|
|response to fibroblast growth factor|
|negative regulation of transmembrane transport|
|ion channel binding|
|regulation of nervous system process|
|adult behavior|
|negative regulation of ion transport|
|growth factor activity|
|regulation of cation channel activity|
|locomotory behavior|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|muscle system process|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|heart development|
|response to growth factor|
|regulation of transmembrane transport|
|actin filament-based process|
|behavior|
|regulation of system process|
|regulation of ion transport|
|enzyme linked receptor protein signaling pathway|
|ion homeostasis|
|circulatory system development|
|positive regulation of transport|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|nervous system process|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|extracellular space|
|homeostatic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18597
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF12 Expression in NALM6 Cells: -0.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>