FGF12

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. {ECO:0000269|PubMed:27164707}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of voltage-gated sodium channel activity
regulation of neuronal action potential
regulation of transmission of nerve impulse
sodium channel regulator activity
positive regulation of sodium ion transport
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
negative regulation of cation channel activity
regulation of membrane depolarization
cardiac muscle cell action potential
regulation of action potential
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
negative regulation of ion transmembrane transporter activity
adult locomotory behavior
cardiac muscle contraction
negative regulation of transporter activity
fibroblast growth factor receptor signaling pathway
negative regulation of cation transmembrane transport
heart contraction
regulation of sodium ion transport
actin-mediated cell contraction
action potential
negative regulation of ion transmembrane transport
heart process
neuromuscular process
striated muscle contraction
cellular response to fibroblast growth factor stimulus
actin filament-based movement
response to fibroblast growth factor
negative regulation of transmembrane transport
ion channel binding
regulation of nervous system process
adult behavior
negative regulation of ion transport
growth factor activity
regulation of cation channel activity
locomotory behavior
muscle contraction
regulation of ion transmembrane transporter activity