FGF14

Gene Information

Official Symbol: FGF14
Official Name: fibroblast growth factor 14
Aliases and Previous Symbols: N/A
Entrez ID: 2259
UniProt: Q92915
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Probably involved in nervous system development and function.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18853
Expression level (log2 read counts): -0.28

Expression Distribution

positive regulation of high voltage-gated calcium channel activity
positive regulation of voltage-gated calcium channel activity
regulation of high voltage-gated calcium channel activity
regulation of synaptic vesicle recycling
regulation of voltage-gated calcium channel activity
positive regulation of calcium ion transmembrane transporter activity
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
regulation of calcium ion transmembrane transporter activity
regulation of postsynaptic membrane potential
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
regulation of synaptic vesicle cycle
positive regulation of calcium ion transport
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
growth factor activity
regulation of cation channel activity
regulation of synaptic plasticity
positive regulation of transmembrane transport
regulation of calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of membrane potential
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
regulation of ion transmembrane transport
regulation of vesicle-mediated transport
regulation of transmembrane transport
regulation of ion transport
regulation of cellular localization
positive regulation of transport
cell-cell signaling
positive regulation of molecular function
regulation of transport