FGF19 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= FGF19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF19
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9965|9965]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95750|O95750]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603891|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:19085950}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of bile acid biosynthetic process|
|negative regulation of bile acid metabolic process|
|regulation of bile acid biosynthetic process|
|regulation of bile acid metabolic process|
|fibroblast growth factor receptor binding|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|positive regulation of glucose import|
|positive regulation of glucose transmembrane transport|
|negative regulation of lipid biosynthetic process|
|regulation of glucose import|
|neural crest cell migration|
|regulation of glucose transmembrane transport|
|neural crest cell development|
|fibroblast growth factor receptor signaling pathway|
|negative regulation of lipid metabolic process|
|stem cell development|
|mesenchymal cell development|
|regulation of steroid biosynthetic process|
|neural crest cell differentiation|
|negative regulation of small molecule metabolic process|
|cellular response to fibroblast growth factor stimulus|
|regulation of steroid metabolic process|
|response to fibroblast growth factor|
|positive regulation of JNK cascade|
|mesenchymal cell differentiation|
|stem cell differentiation|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|ameboidal-type cell migration|
|regulation of cellular ketone metabolic process|
|regulation of JNK cascade|
|regulation of lipid biosynthetic process|
|positive regulation of transmembrane transport|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein kinase B signaling|
|mesenchyme development|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of ERK1 and ERK2 cascade|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|heart development|
|response to growth factor|
|positive regulation of MAPK cascade|
|regulation of transmembrane transport|
|response to bacterium|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|circulatory system development|
|positive regulation of cell population proliferation|
|cell migration|
|protein phosphorylation|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.07|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18278
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF19 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>