FGF19

Gene Information

Official Symbol: FGF19
Official Name: fibroblast growth factor 19
Aliases and Previous Symbols: N/A
Entrez ID: 9965
UniProt: O95750
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:19085950}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18278
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
IL-3 9ng/ml R08 exp493	-2.07
MS023 7μM R03 exp135	-1.74

negative regulation of bile acid biosynthetic process
negative regulation of bile acid metabolic process
regulation of bile acid biosynthetic process
regulation of bile acid metabolic process
fibroblast growth factor receptor binding
negative regulation of steroid biosynthetic process
negative regulation of steroid metabolic process
positive regulation of glucose import
positive regulation of glucose transmembrane transport
negative regulation of lipid biosynthetic process
regulation of glucose import
neural crest cell migration
regulation of glucose transmembrane transport
neural crest cell development
fibroblast growth factor receptor signaling pathway
negative regulation of lipid metabolic process
stem cell development
mesenchymal cell development
regulation of steroid biosynthetic process
neural crest cell differentiation
negative regulation of small molecule metabolic process
cellular response to fibroblast growth factor stimulus
regulation of steroid metabolic process
response to fibroblast growth factor
positive regulation of JNK cascade
mesenchymal cell differentiation
stem cell differentiation
growth factor activity
positive regulation of protein kinase B signaling
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
ameboidal-type cell migration
regulation of cellular ketone metabolic process
regulation of JNK cascade
regulation of lipid biosynthetic process
positive regulation of transmembrane transport
positive regulation of ERK1 and ERK2 cascade
regulation of protein kinase B signaling
mesenchyme development
regulation of stress-activated MAPK cascade