FGF20

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009].
UniProt Summary: Neurotrophic factor that regulates central nervous development and function. {ECO:0000269|PubMed:16597617}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

receptor-receptor interaction
positive regulation of dopaminergic neuron differentiation
regulation of dopaminergic neuron differentiation
heparan sulfate proteoglycan binding
fibroblast growth factor receptor binding
regulation of cardiac muscle cell proliferation
regulation of dopamine secretion
inner ear receptor cell differentiation
mechanoreceptor differentiation
regulation of cardiac muscle tissue growth
regulation of catecholamine secretion
regulation of heart growth
regulation of cardiac muscle tissue development
fibroblast growth factor receptor signaling pathway
regulation of organ growth
regulation of amine transport
regulation of response to drug
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
negative regulation of neuron apoptotic process
growth factor activity
positive regulation of protein kinase B signaling
inner ear development
regulation of neuron apoptotic process
negative regulation of neuron death
positive regulation of ERK1 and ERK2 cascade
regulation of protein kinase B signaling
ear development
regulation of ERK1 and ERK2 cascade
regulation of neuron death
regulation of developmental growth
signaling receptor binding
positive regulation of neuron differentiation
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of neurogenesis
cellular response to growth factor stimulus