FGF21 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF21
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26291|26291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NSA1|Q9NSA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609436|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. {ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:17623664}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to methionine|
|positive regulation of low-density lipoprotein particle receptor biosynthetic process|
|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|
|positive regulation of triglyceride catabolic process|
|endothelial cell apoptotic process|
|regulation of low-density lipoprotein particle receptor biosynthetic process|
|regulation of low-density lipoprotein particle clearance|
|regulation of triglyceride catabolic process|
|positive regulation of receptor biosynthetic process|
|cellular response to low-density lipoprotein particle stimulus|
|regulation of lipoprotein particle clearance|
|positive regulation of triglyceride metabolic process|
|fibroblast growth factor receptor binding|
|regulation of receptor biosynthetic process|
|positive regulation of lipid catabolic process|
|cellular response to glucagon stimulus|
|response to lipoprotein particle|
|epithelial cell apoptotic process|
|cellular response to lipoprotein particle stimulus|
|negative regulation of endothelial cell apoptotic process|
|regulation of triglyceride metabolic process|
|response to glucagon|
|positive regulation of glucose import|
|negative regulation of epithelial cell apoptotic process|
|positive regulation of glucose transmembrane transport|
|regulation of endothelial cell apoptotic process|
|regulation of lipid catabolic process|
|regulation of glucose import|
|response to activity|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|regulation of glucose transmembrane transport|
|regulation of epithelial cell apoptotic process|
|fibroblast growth factor receptor signaling pathway|
|cellular response to carbohydrate stimulus|
|cell|
|cellular glucose homeostasis|
|positive regulation of cold-induced thermogenesis|
|endoplasmic reticulum unfolded protein response|
|cellular response to fibroblast growth factor stimulus|
|response to amino acid|
|response to fibroblast growth factor|
|cellular response to unfolded protein|
|response to glucose|
|positive regulation of lipid metabolic process|
|response to hexose|
|regulation of cold-induced thermogenesis|
|response to monosaccharide|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|growth factor activity|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to topologically incorrect protein|
|positive regulation of transmembrane transport|
|negative regulation of neuron death|
|positive regulation of ERK1 and ERK2 cascade|
|response to endoplasmic reticulum stress|
|cellular response to peptide hormone stimulus|
|regulation of ERK1 and ERK2 cascade|
|regulation of neuron death|
|cellular response to peptide|
|response to acid chemical|
|positive regulation of cellular catabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|cellular response to drug|
|positive regulation of catabolic process|
|response to peptide|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to extracellular stimulus|
|response to growth factor|
|positive regulation of MAPK cascade|
|regulation of transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|apoptotic process|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.88|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5838
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF21 Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>