FGF21

Gene Information

Official Symbol: FGF21
Official Name: fibroblast growth factor 21
Aliases and Previous Symbols: N/A
Entrez ID: 26291
UniProt: Q9NSA1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016].
UniProt Summary: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. {ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:17623664}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5838
Expression level (log2 read counts): -6.02

Expression Distribution

Screen	Score
VE-822 0.04μM R06 exp300	1.88
Citral 50μM R06 exp274	2.35

response to methionine
positive regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
positive regulation of triglyceride catabolic process
endothelial cell apoptotic process
regulation of low-density lipoprotein particle receptor biosynthetic process
regulation of low-density lipoprotein particle clearance
regulation of triglyceride catabolic process
positive regulation of receptor biosynthetic process
cellular response to low-density lipoprotein particle stimulus
regulation of lipoprotein particle clearance
positive regulation of triglyceride metabolic process
fibroblast growth factor receptor binding
regulation of receptor biosynthetic process
positive regulation of lipid catabolic process
cellular response to glucagon stimulus
response to lipoprotein particle
epithelial cell apoptotic process
cellular response to lipoprotein particle stimulus
negative regulation of endothelial cell apoptotic process
regulation of triglyceride metabolic process
response to glucagon
positive regulation of glucose import
negative regulation of epithelial cell apoptotic process
positive regulation of glucose transmembrane transport
regulation of endothelial cell apoptotic process
regulation of lipid catabolic process
regulation of glucose import
response to activity
cellular response to glucose stimulus
cellular response to hexose stimulus
cellular response to monosaccharide stimulus
regulation of glucose transmembrane transport
regulation of epithelial cell apoptotic process
fibroblast growth factor receptor signaling pathway
cellular response to carbohydrate stimulus
cell
cellular glucose homeostasis
positive regulation of cold-induced thermogenesis
endoplasmic reticulum unfolded protein response