FGF22

Entrez Summary: N/A
UniProt Summary: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. {ECO:0000269|PubMed:16597617}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fibroblast growth factor receptor binding
fibroblast growth factor receptor signaling pathway
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
growth factor activity
positive regulation of protein kinase B signaling
regulation of protein kinase B signaling
MAPK cascade
signal transduction by protein phosphorylation
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
cell surface
enzyme linked receptor protein signaling pathway
nucleolus
protein phosphorylation
Golgi apparatus
positive regulation of intracellular signal transduction
cellular response to endogenous stimulus
phosphorylation
response to endogenous stimulus
extracellular space
positive regulation of signal transduction
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
extracellular region