FGF3

Gene Information

Official Symbol: FGF3
Official Name: fibroblast growth factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 2248
UniProt: P11487
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. {ECO:0000269|PubMed:8663044}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18638
Expression level (log2 read counts): -6.6

Expression Distribution

fibroblast growth factor receptor binding
negative regulation of cardiac muscle tissue development
negative regulation of striated muscle tissue development
negative regulation of muscle organ development
negative regulation of muscle tissue development
regulation of cardiac muscle tissue development
fibroblast growth factor receptor signaling pathway
positive regulation of cell division
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
growth factor activity
positive regulation of protein kinase B signaling
regulation of cell division
regulation of protein kinase B signaling
MAPK cascade
signal transduction by protein phosphorylation
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
enzyme linked receptor protein signaling pathway
positive regulation of cell population proliferation
negative regulation of developmental process
protein phosphorylation
positive regulation of intracellular signal transduction
cell-cell signaling
negative regulation of multicellular organismal process
cellular response to endogenous stimulus
phosphorylation
response to endogenous stimulus
regulation of cell population proliferation
positive regulation of signal transduction
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
extracellular region