FGF4 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF4
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2249|2249]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08620|P08620]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. {ECO:0000269|PubMed:8663044}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chondroblast differentiation|
|regulation of endothelial cell chemotaxis to fibroblast growth factor|
|regulation of cell chemotaxis to fibroblast growth factor|
|cranial suture morphogenesis|
|apoptotic process involved in morphogenesis|
|mesenchymal cell proliferation|
|craniofacial suture morphogenesis|
|cartilage condensation|
|fibroblast growth factor receptor binding|
|regulation of endothelial cell chemotaxis|
|cell aggregation|
|apoptotic process involved in development|
|embryonic hindlimb morphogenesis|
|hindlimb morphogenesis|
|cranial skeletal system development|
|fibroblast growth factor receptor signaling pathway|
|odontogenesis of dentin-containing tooth|
|positive regulation of cell division|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|cellular response to fibroblast growth factor stimulus|
|bone morphogenesis|
|response to fibroblast growth factor|
|odontogenesis|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|stem cell population maintenance|
|maintenance of cell number|
|appendage morphogenesis|
|limb morphogenesis|
|regulation of endothelial cell migration|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of cell division|
|heparin binding|
|cartilage development|
|limb development|
|appendage development|
|bone development|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|connective tissue development|
|skeletal system morphogenesis|
|regulation of cellular response to growth factor stimulus|
|regulation of ERK1 and ERK2 cascade|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|skeletal system development|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|positive regulation of MAPK cascade|
|cell population proliferation|
|embryonic morphogenesis|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|animal organ morphogenesis|
|protein phosphorylation|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10502
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF4 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>