FGF4
Gene Information
- Official Symbol: FGF4
- Official Name: fibroblast growth factor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 2249
- UniProt: P08620
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. {ECO:0000269|PubMed:8663044}.
Pfam Domains GO Terms
Pfam Domains
| FGF |
GO Terms
| chondroblast differentiation |
| regulation of endothelial cell chemotaxis to fibroblast growth factor |
| regulation of cell chemotaxis to fibroblast growth factor |
| cranial suture morphogenesis |
| apoptotic process involved in morphogenesis |
| mesenchymal cell proliferation |
| craniofacial suture morphogenesis |
| cartilage condensation |
| fibroblast growth factor receptor binding |
| regulation of endothelial cell chemotaxis |
| cell aggregation |
| apoptotic process involved in development |
| embryonic hindlimb morphogenesis |
| hindlimb morphogenesis |
| cranial skeletal system development |
| fibroblast growth factor receptor signaling pathway |
| odontogenesis of dentin-containing tooth |
| positive regulation of cell division |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| cellular response to fibroblast growth factor stimulus |
| bone morphogenesis |
| response to fibroblast growth factor |
| odontogenesis |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| stem cell population maintenance |
| maintenance of cell number |
| appendage morphogenesis |
| limb morphogenesis |
| regulation of endothelial cell migration |
| growth factor activity |
| positive regulation of protein kinase B signaling |
| regulation of cell division |
| heparin binding |
| cartilage development |
| limb development |
| appendage development |
| bone development |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| regulation of protein kinase B signaling |
| regulation of epithelial cell migration |
| connective tissue development |
| skeletal system morphogenesis |
| regulation of cellular response to growth factor stimulus |
| regulation of ERK1 and ERK2 cascade |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| skeletal system development |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to growth factor |
| positive regulation of MAPK cascade |
| cell population proliferation |
| embryonic morphogenesis |
| enzyme linked receptor protein signaling pathway |
| regulation of MAPK cascade |
| regulation of cell migration |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| apoptotic process |
| animal organ morphogenesis |
| protein phosphorylation |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| positive regulation of phosphorylation |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| phosphorylation |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10502
- Expression level (log2 read counts): -6.6
Expression Distribution
FGF4 Expression in NALM6 Cells: -6.6
