FGF7

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

secretion by lung epithelial cell involved in lung growth
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
positive regulation of epithelial cell proliferation involved in lung morphogenesis
lung growth
regulation of epithelial cell proliferation involved in lung morphogenesis
mesenchymal-epithelial cell signaling
regulation of branching involved in salivary gland morphogenesis
positive regulation of keratinocyte migration
positive regulation of keratinocyte proliferation
regulation of keratinocyte migration
mesenchymal cell proliferation
branching involved in salivary gland morphogenesis
fibroblast growth factor receptor binding
hair follicle morphogenesis
protein localization to cell surface
epidermis morphogenesis
salivary gland morphogenesis
salivary gland development
regulation of keratinocyte proliferation
chemoattractant activity
exocrine system development
positive chemotaxis
regulation of morphogenesis of a branching structure
actin cytoskeleton reorganization
hair follicle development
skin epidermis development
hair cycle process
molting cycle process
fibroblast growth factor receptor signaling pathway
positive regulation of animal organ morphogenesis
positive regulation of cell division
molting cycle
hair cycle
organ growth
gland morphogenesis
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
positive regulation of epithelial cell migration
morphogenesis of a branching epithelium
growth factor activity