FGFBP1

Gene Information

Official Symbol: FGFBP1
Official Name: fibroblast growth factor binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9982
UniProt: Q14512
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. {ECO:0000269|PubMed:11509569, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605, ECO:0000269|PubMed:9334727}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9608
Expression level (log2 read counts): -7.68

Expression Distribution

positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of cell migration involved in sprouting angiogenesis
fibroblast growth factor binding
regulation of fibroblast growth factor receptor signaling pathway
regulation of cell migration involved in sprouting angiogenesis
positive regulation of sprouting angiogenesis
positive regulation of blood vessel endothelial cell migration
regulation of sprouting angiogenesis
fibroblast growth factor receptor signaling pathway
regulation of blood vessel endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of endothelial cell migration
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
regulation of endothelial cell migration
positive regulation of angiogenesis
heparin binding
positive regulation of vasculature development
positive regulation of epithelial cell proliferation
regulation of epithelial cell migration
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
positive regulation of cell migration
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell motility
response to growth factor
positive regulation of cellular component movement
positive regulation of locomotion
cell surface
negative regulation of cell population proliferation
enzyme linked receptor protein signaling pathway
regulation of cell migration
regulation of cell motility