FGFBP3

Entrez Summary: N/A
UniProt Summary: Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. {ECO:0000269|PubMed:18669637}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nicotinamide 2000μM R01 exp50	-1.87
HMS-I2 1μM R06 exp286	-1.74
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.84
Etoposide 0.3μM R05 exp199	2.21

positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of vascular permeability
fibroblast growth factor binding
regulation of fibroblast growth factor receptor signaling pathway
regulation of vascular permeability
vascular process in circulatory system
heparin binding
regulation of cellular response to growth factor stimulus
collagen-containing extracellular matrix
blood circulation
circulatory system process
cell-cell signaling
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
extracellular region
system process