FGFR4 [The Human Chemical-Genetic Interaction Map Project]

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======= FGFR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGFR4
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2264|2264]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22455|P22455]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGFR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGFR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134935|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to bile acid|
|fibroblast growth factor-activated receptor activity|
|regulation of bile acid biosynthetic process|
|divalent inorganic anion homeostasis|
|regulation of bile acid metabolic process|
|trivalent inorganic anion homeostasis|
|phosphate ion homeostasis|
|regulation of extracellular matrix disassembly|
|fibroblast growth factor binding|
|monovalent inorganic anion homeostasis|
|regulation of extracellular matrix organization|
|transmembrane receptor protein tyrosine kinase activity|
|anion homeostasis|
|positive regulation of DNA biosynthetic process|
|cholesterol homeostasis|
|fibroblast growth factor receptor signaling pathway|
|sterol homeostasis|
|regulation of steroid biosynthetic process|
|transport vesicle|
|cellular response to fibroblast growth factor stimulus|
|regulation of DNA biosynthetic process|
|regulation of steroid metabolic process|
|response to fibroblast growth factor|
|lipid homeostasis|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|positive regulation of protein kinase B signaling|
|heparin binding|
|regulation of cellular ketone metabolic process|
|cell-cell junction|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|positive regulation of DNA metabolic process|
|protein autophosphorylation|
|receptor complex|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein kinase B signaling|
|endosome|
|regulation of ERK1 and ERK2 cascade|
|response to acid chemical|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|positive regulation of MAPK cascade|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of MAPK cascade|
|ion homeostasis|
|response to lipid|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell migration|
|protein phosphorylation|
|Golgi apparatus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.7|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.71|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.76|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7278
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGFR4 Expression in NALM6 Cells: 0.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>