FGFR4

Entrez Summary: The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to bile acid
fibroblast growth factor-activated receptor activity
regulation of bile acid biosynthetic process
divalent inorganic anion homeostasis
regulation of bile acid metabolic process
trivalent inorganic anion homeostasis
phosphate ion homeostasis
regulation of extracellular matrix disassembly
fibroblast growth factor binding
monovalent inorganic anion homeostasis
regulation of extracellular matrix organization
transmembrane receptor protein tyrosine kinase activity
anion homeostasis
positive regulation of DNA biosynthetic process
cholesterol homeostasis
fibroblast growth factor receptor signaling pathway
sterol homeostasis
regulation of steroid biosynthetic process
transport vesicle
cellular response to fibroblast growth factor stimulus
regulation of DNA biosynthetic process
regulation of steroid metabolic process
response to fibroblast growth factor
lipid homeostasis
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
positive regulation of protein kinase B signaling
heparin binding
regulation of cellular ketone metabolic process
cell-cell junction
glucose homeostasis
carbohydrate homeostasis
regulation of lipid biosynthetic process
positive regulation of DNA metabolic process
protein autophosphorylation
receptor complex
positive regulation of ERK1 and ERK2 cascade
regulation of protein kinase B signaling
endosome
regulation of ERK1 and ERK2 cascade