FGG
Gene Information
- Official Symbol: FGG
- Official Name: fibrinogen gamma chain
- Aliases and Previous Symbols: N/A
- Entrez ID: 2266
- UniProt: P02679
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Fib alpha |
| Fibrinogen C |
GO Terms
| platelet maturation |
| fibrinogen complex |
| plasminogen activation |
| negative regulation of platelet aggregation |
| platelet alpha granule |
| negative regulation of homotypic cell-cell adhesion |
| positive regulation of heterotypic cell-cell adhesion |
| regulation of platelet aggregation |
| negative regulation of platelet activation |
| fibrinolysis |
| regulation of homotypic cell-cell adhesion |
| protein activation cascade |
| regulation of heterotypic cell-cell adhesion |
| blood coagulation, fibrin clot formation |
| negative regulation of endothelial cell apoptotic process |
| positive regulation of vasoconstriction |
| regulation of platelet activation |
| cellular response to interleukin-6 |
| response to interleukin-6 |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| positive regulation of substrate adhesion-dependent cell spreading |
| zymogen activation |
| negative regulation of epithelial cell apoptotic process |
| platelet aggregation |
| negative regulation of blood coagulation |
| regulation of endothelial cell apoptotic process |
| negative regulation of hemostasis |
| negative regulation of coagulation |
| regulation of substrate adhesion-dependent cell spreading |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| regulation of vasoconstriction |
| cell adhesion molecule binding |
| homotypic cell-cell adhesion |
| platelet alpha granule lumen |
| positive regulation of blood circulation |
| negative regulation of wound healing |
| regulation of epithelial cell apoptotic process |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of coagulation |
| negative regulation of response to wounding |
| protein polymerization |
| positive regulation of exocytosis |
| positive regulation of peptide hormone secretion |
| toll-like receptor signaling pathway |
| negative regulation of extrinsic apoptotic signaling pathway |
| positive regulation of cell-substrate adhesion |
| cell-matrix adhesion |
| positive regulation of hormone secretion |
| pattern recognition receptor signaling pathway |
| platelet degranulation |
| extracellular matrix structural constituent |
| anatomical structure maturation |
| regulation of wound healing |
| platelet activation |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| blood microparticle |
| response to calcium ion |
| regulation of extrinsic apoptotic signaling pathway |
| positive regulation of cell morphogenesis involved in differentiation |
| cell maturation |
| protein processing |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| regulation of response to wounding |
| vascular process in circulatory system |
| peptide secretion |
| cellular response to interleukin-1 |
| negative regulation of cell-cell adhesion |
| cell-substrate adhesion |
| structural molecule activity |
| negative regulation of cell activation |
| response to interleukin-1 |
| regulation of peptide hormone secretion |
| regulation of cell-substrate adhesion |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of exocytosis |
| negative regulation of apoptotic signaling pathway |
| protein maturation |
| innate immune response-activating signal transduction |
| developmental maturation |
| positive regulation of cell-cell adhesion |
| activation of innate immune response |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| blood coagulation |
| coagulation |
| hemostasis |
| regulation of cell morphogenesis involved in differentiation |
| endoplasmic reticulum lumen |
| signaling receptor binding |
| extracellular matrix organization |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| post-translational protein modification |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| response to metal ion |
| extracellular structure organization |
| blood circulation |
| external side of plasma membrane |
| circulatory system process |
| regulation of cell-cell adhesion |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| positive regulation of protein transport |
| positive regulation of secretion |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of defense response |
| wound healing |
| regulation of cell morphogenesis |
| regulation of peptide secretion |
| regulation of body fluid levels |
| cell-cell adhesion |
| positive regulation of multi-organism process |
| regulation of anatomical structure size |
| regulation of response to biotic stimulus |
| regulation of hormone levels |
| response to inorganic substance |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| immune response-activating signal transduction |
| response to wounding |
| regulation of system process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cell surface |
| activation of immune response |
| regulation of cell activation |
| regulation of cell adhesion |
| regulated exocytosis |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| exocytosis |
| regulation of secretion |
| cellular protein-containing complex assembly |
| positive regulation of immune response |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| positive regulation of cell differentiation |
| positive regulation of transport |
| negative regulation of cell death |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| regulation of response to external stimulus |
| response to cytokine |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| peptide transport |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| extracellular region |
| vesicle-mediated transport |
| system process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pyrazinamide 100μM R08 exp516 | 1.79 |
| Radicicol 0.16μM R05 exp242 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18067
- Expression level (log2 read counts): -7.68
Expression Distribution
FGG Expression in NALM6 Cells: -7.68
