FHL1 [The Human Chemical-Genetic Interaction Map Project]

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======= FHL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FHL1
  * **<color #00a2e8>Official Name</color>**: four and a half LIM domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2273|2273]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13642|Q13642]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FHL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FHL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300163|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of membrane depolarization|
|positive regulation of potassium ion transport|
|regulation of potassium ion transmembrane transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of G2/M transition of mitotic cell cycle|
|regulation of potassium ion transport|
|negative regulation of cell cycle G2/M phase transition|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|ion channel binding|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|negative regulation of cell growth|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|negative regulation of growth|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|muscle organ development|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|regulation of mitotic cell cycle phase transition|
|focal adhesion|
|regulation of cell growth|
|regulation of membrane potential|
|regulation of cell cycle phase transition|
|muscle structure development|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|regulation of growth|
|regulation of ion transport|
|regulation of cell cycle process|
|molecular function|
|ion homeostasis|
|animal organ morphogenesis|
|positive regulation of transport|
|chemical homeostasis|
|regulation of cell cycle|
|homeostatic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp303|39°C R06 exp303]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9454
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FHL1 Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>