FHL1

Gene Information

Official Symbol: FHL1
Official Name: four and a half LIM domains 1
Aliases and Previous Symbols: N/A
Entrez ID: 2273
UniProt: Q13642
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9454
Expression level (log2 read counts): 3.77

Expression Distribution

regulation of membrane depolarization
positive regulation of potassium ion transport
regulation of potassium ion transmembrane transporter activity
regulation of potassium ion transmembrane transport
negative regulation of G2/M transition of mitotic cell cycle
regulation of potassium ion transport
negative regulation of cell cycle G2/M phase transition
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
ion channel binding
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
negative regulation of cell growth
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
negative regulation of cell cycle phase transition
negative regulation of growth
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
muscle organ development
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of mitotic cell cycle phase transition
focal adhesion
regulation of cell growth
regulation of membrane potential
regulation of cell cycle phase transition
muscle structure development
regulation of ion transmembrane transport
regulation of transmembrane transport
negative regulation of cell cycle
regulation of mitotic cell cycle
regulation of growth
regulation of ion transport
regulation of cell cycle process