FHL2

Gene Information

Official Symbol: FHL2
Official Name: four and a half LIM domains 2
Aliases and Previous Symbols: N/A
Entrez ID: 2274
UniProt: Q14192
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016].
UniProt Summary: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14148
Expression level (log2 read counts): 2.72

Expression Distribution

Screen	Score
SNS-032 15μM R08 exp443	-2.39
Glyphosate 1000μM R06 exp283	1.75

negative regulation of calcineurin-NFAT signaling cascade
negative regulation of calcineurin-mediated signaling
negative regulation of calcium-mediated signaling
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
androgen receptor signaling pathway
androgen receptor binding
intracellular steroid hormone receptor signaling pathway
regulation of calcium-mediated signaling
steroid hormone mediated signaling pathway
Z disc
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
transcription coactivator activity
response to steroid hormone
transcription factor binding
regulation of lipid metabolic process
focal adhesion
negative regulation of intracellular signal transduction
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
response to lipid
negative regulation of transcription by RNA polymerase II
negative regulation of apoptotic process
negative regulation of programmed cell death
response to hormone
response to organic cyclic compound
negative regulation of cell death
identical protein binding
negative regulation of transcription, DNA-templated
cellular response to endogenous stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process