FKBP6

Entrez Summary: The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

FK506 binding
piRNA metabolic process
DNA methylation involved in gamete generation
synaptonemal complex
positive regulation of viral genome replication
Hsp90 protein binding
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
DNA alkylation
DNA methylation
peptidyl-proline modification
positive regulation of viral life cycle
DNA methylation or demethylation
gene silencing by RNA
DNA modification
regulation of viral genome replication
positive regulation of viral process
regulation of viral life cycle
gene silencing
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
meiotic cell cycle
protein folding
macromolecule methylation
methylation
cellular process involved in reproduction in multicellular organism
ncRNA metabolic process
positive regulation of multi-organism process
spermatogenesis
male gamete generation
gamete generation
DNA metabolic process
regulation of multi-organism process
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
peptidyl-amino acid modification
multi-organism reproductive process
identical protein binding
cell cycle