FLG2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Salinomycin 3.5μM R08 exp521	-2.17
Etoposide 0.1μM R05 exp198	-1.91
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.78
Q15 1 to 2μM on day4 R04 exp164	1.77

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

keratohyalin granule
structural constituent of epidermis
transition metal ion binding
establishment of skin barrier
regulation of water loss via skin
epidermis morphogenesis
tertiary granule lumen
cornified envelope
multicellular organismal water homeostasis
water homeostasis
multicellular organismal homeostasis
skin development
epidermis development
morphogenesis of an epithelium
neutrophil degranulation
neutrophil activation involved in immune response
regulation of body fluid levels
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
tissue morphogenesis
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
calcium ion binding
leukocyte mediated immunity
exocytosis
leukocyte activation
cell adhesion
biological adhesion
secretion by cell
export from cell
cell activation
immune effector process
chemical homeostasis
epithelium development