FLOT1
Gene Information
- Official Symbol: FLOT1
- Official Name: flotillin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10211
- UniProt: O75955
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Pfam Domains GO Terms
Pfam Domains
| Band 7 |
GO Terms
| positive regulation of cell adhesion molecule production |
| dsRNA transport |
| regulation of cell adhesion molecule production |
| plasma membrane raft assembly |
| positive regulation of synaptic transmission, dopaminergic |
| positive regulation of toll-like receptor 3 signaling pathway |
| protein localization to membrane raft |
| flotillin complex |
| plasma membrane raft organization |
| regulation of toll-like receptor 3 signaling pathway |
| positive regulation of cell-cell adhesion mediated by cadherin |
| membrane raft assembly |
| uropod |
| dopaminergic synapse |
| protein kinase C signaling |
| positive regulation of heterotypic cell-cell adhesion |
| regulation of synaptic transmission, dopaminergic |
| cellular response to exogenous dsRNA |
| regulation of cell-cell adhesion mediated by cadherin |
| positive regulation of myoblast fusion |
| regulation of neurotransmitter uptake |
| regulation of toll-like receptor 4 signaling pathway |
| cell-cell contact zone |
| regulation of myoblast fusion |
| membrane raft organization |
| cellular response to dsRNA |
| positive regulation of toll-like receptor signaling pathway |
| positive regulation of skeletal muscle tissue development |
| regulation of heterotypic cell-cell adhesion |
| positive regulation of syncytium formation by plasma membrane fusion |
| regulation of syncytium formation by plasma membrane fusion |
| positive regulation of interferon-beta production |
| centriolar satellite |
| positive regulation of myotube differentiation |
| positive regulation of cell junction assembly |
| ionotropic glutamate receptor binding |
| membrane assembly |
| presynaptic active zone |
| COP9 signalosome |
| membrane biogenesis |
| response to exogenous dsRNA |
| regulation of interferon-beta production |
| regulation of skeletal muscle tissue development |
| cortical actin cytoskeleton |
| response to dsRNA |
| regulation of receptor internalization |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| extracellular matrix disassembly |
| GABA-ergic synapse |
| regulation of toll-like receptor signaling pathway |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| caveola |
| positive regulation of type I interferon production |
| positive regulation of muscle cell differentiation |
| regulation of cell junction assembly |
| plasma membrane organization |
| positive regulation of protein binding |
| sarcolemma |
| positive regulation of endocytosis |
| regulation of receptor-mediated endocytosis |
| melanosome |
| regulation of striated muscle cell differentiation |
| protease binding |
| cell-cell adherens junction |
| regulation of type I interferon production |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of Rho protein signal transduction |
| regulation of neurotransmitter transport |
| positive regulation of synaptic transmission |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of muscle cell differentiation |
| microtubule organizing center |
| cell-cell junction |
| protein stabilization |
| positive regulation of binding |
| lamellipodium |
| protein localization to plasma membrane |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| basolateral plasma membrane |
| regulation of endocytosis |
| RNA localization |
| regulation of protein binding |
| membrane raft |
| protein localization to cell periphery |
| nucleobase-containing compound transport |
| regulation of Ras protein signal transduction |
| cytoplasmic vesicle |
| positive regulation of cell-cell adhesion |
| early endosome |
| response to endoplasmic reticulum stress |
| positive regulation of DNA-binding transcription factor activity |
| endosome |
| regulation of protein stability |
| lysosomal membrane |
| apical plasma membrane |
| protein homooligomerization |
| extracellular matrix organization |
| positive regulation of innate immune response |
| regulation of small GTPase mediated signal transduction |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| positive regulation of response to biotic stimulus |
| axonogenesis |
| regulation of binding |
| extracellular structure organization |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| positive regulation of cell adhesion |
| axon development |
| focal adhesion |
| endomembrane system organization |
| regulation of DNA-binding transcription factor activity |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of defense response |
| neuron projection morphogenesis |
| protein localization to membrane |
| plasma membrane bounded cell projection morphogenesis |
| protein heterodimerization activity |
| cell projection morphogenesis |
| positive regulation of multi-organism process |
| cell part morphogenesis |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| regulation of response to biotic stimulus |
| cellular response to organic cyclic compound |
| regulation of vesicle-mediated transport |
| cell morphogenesis involved in differentiation |
| positive regulation of response to external stimulus |
| cellular response to nitrogen compound |
| neuron projection development |
| regulation of cell adhesion |
| regulation of cytokine production |
| cell morphogenesis |
| regulation of defense response |
| regulation of multi-organism process |
| neuron development |
| cellular component morphogenesis |
| membrane organization |
| positive regulation of immune response |
| response to organic cyclic compound |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| positive regulation of transport |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| regulation of response to external stimulus |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| protein-containing complex assembly |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3123
- Expression level (log2 read counts): 6.39
Expression Distribution
FLOT1 Expression in NALM6 Cells: 6.39
