FLRT1

Entrez Summary: N/A
UniProt Summary: Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. {ECO:0000250|UniProtKB:Q6RKD8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neuron projection terminus
fibroblast growth factor receptor binding
neuronal cell body membrane
neuron projection extension
positive regulation of synapse assembly
protein binding, bridging
fibroblast growth factor receptor signaling pathway
developmental cell growth
cell growth
dendrite development
regulation of synapse assembly
cellular response to fibroblast growth factor stimulus
developmental growth involved in morphogenesis
response to fibroblast growth factor
cytoplasmic vesicle membrane
cell-cell junction
regulation of synapse organization
regulation of synapse structure or activity
extracellular matrix
cytoplasmic vesicle
developmental growth
growth
focal adhesion
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
positive regulation of cellular component biogenesis
response to growth factor
positive regulation of nervous system development
neuron projection development
perinuclear region of cytoplasm
enzyme linked receptor protein signaling pathway
cell morphogenesis
neuron development
cellular component morphogenesis
regulation of nervous system development
cell adhesion