FMN1 [The Human Chemical-Genetic Interaction Map Project]

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======= FMN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FMN1
  * **<color #00a2e8>Official Name</color>**: formin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=342184|342184]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q68DA7|Q68DA7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FMN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FMN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ureteric bud invasion|
|metanephric renal vesicle formation|
|ureteric bud elongation|
|renal vesicle formation|
|metanephric renal vesicle morphogenesis|
|renal vesicle morphogenesis|
|renal vesicle development|
|positive regulation of actin nucleation|
|metanephric nephron morphogenesis|
|positive regulation of focal adhesion assembly|
|regulation of actin nucleation|
|metanephros morphogenesis|
|positive regulation of adherens junction organization|
|metanephric nephron development|
|actin nucleation|
|positive regulation of cell junction assembly|
|hindlimb morphogenesis|
|forelimb morphogenesis|
|positive regulation of cell-matrix adhesion|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|adherens junction|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|regulation of adherens junction organization|
|nephron morphogenesis|
|renal tubule morphogenesis|
|nephron tubule development|
|renal tubule development|
|actin filament|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|regulation of cell junction assembly|
|mesonephros development|
|positive regulation of actin filament polymerization|
|nephron epithelium development|
|regulation of cell-matrix adhesion|
|developmental growth involved in morphogenesis|
|positive regulation of cell-substrate adhesion|
|nephron development|
|positive regulation of protein polymerization|
|kidney epithelium development|
|SH3 domain binding|
|appendage morphogenesis|
|limb morphogenesis|
|regulation of actin filament polymerization|
|limb development|
|appendage development|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of cell-substrate adhesion|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|microtubule binding|
|skeletal system morphogenesis|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|kidney development|
|actin binding|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|positive regulation of cell adhesion|
|morphogenesis of an epithelium|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|skeletal system development|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|tissue morphogenesis|
|actin filament-based process|
|positive regulation of organelle organization|
|tube morphogenesis|
|regulation of cell adhesion|
|tube development|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cytoskeleton organization|
|epithelium development|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|tissue development|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.72|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.72|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.82|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7087
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FMN1 Expression in NALM6 Cells: 2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>