FMN1

Entrez Summary: This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].
UniProt Summary: Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ureteric bud invasion
metanephric renal vesicle formation
ureteric bud elongation
renal vesicle formation
metanephric renal vesicle morphogenesis
renal vesicle morphogenesis
renal vesicle development
positive regulation of actin nucleation
metanephric nephron morphogenesis
positive regulation of focal adhesion assembly
regulation of actin nucleation
metanephros morphogenesis
positive regulation of adherens junction organization
metanephric nephron development
actin nucleation
positive regulation of cell junction assembly
hindlimb morphogenesis
forelimb morphogenesis
positive regulation of cell-matrix adhesion
ureteric bud morphogenesis
mesonephric tubule morphogenesis
regulation of focal adhesion assembly
regulation of cell-substrate junction assembly
adherens junction
nephron tubule morphogenesis
nephron epithelium morphogenesis
regulation of adherens junction organization
nephron morphogenesis
renal tubule morphogenesis
nephron tubule development
renal tubule development
actin filament
metanephros development
kidney morphogenesis
ureteric bud development
mesonephric epithelium development
mesonephric tubule development
regulation of cell junction assembly
mesonephros development
positive regulation of actin filament polymerization