FMNL3

Entrez Summary: N/A
UniProt Summary: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. {ECO:0000250|UniProtKB:Q6NXC0, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22275430}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GTPase activating protein binding
Rho GTPase binding
cortical actin cytoskeleton organization
cortical cytoskeleton organization
regulation of cell shape
actin binding
angiogenesis
blood vessel morphogenesis
blood vessel development
regulation of cell morphogenesis
actin cytoskeleton organization
vasculature development
cardiovascular system development
actin filament-based process
tube morphogenesis
intracellular membrane-bounded organelle
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
cell migration
Golgi apparatus
regulation of anatomical structure morphogenesis
cell motility
localization of cell
cytoskeleton organization
locomotion
movement of cell or subcellular component