FMO1 [The Human Chemical-Genetic Interaction Map Project]

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======= FMO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FMO1
  * **<color #00a2e8>Official Name</color>**: flavin containing dimethylaniline monoxygenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2326|2326]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01740|Q01740]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FMO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FMO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyr redox 2|
|FMO-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADPH oxidation|
|N,N-dimethylaniline monooxygenase activity|
|toxin metabolic process|
|NADP metabolic process|
|monooxygenase activity|
|NADP binding|
|secondary metabolic process|
|flavin adenine dinucleotide binding|
|response to osmotic stress|
|xenobiotic metabolic process|
|cellular response to xenobiotic stimulus|
|response to xenobiotic stimulus|
|endoplasmic reticulum lumen|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|drug metabolic process|
|response to bacterium|
|response to lipid|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|organic acid metabolic process|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FMO1 Expression in NALM6 Cells: 3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>